Welcome to the website of the Angiogenesis
Laboratory Amsterdam
Angiogenesis is a key
process in cancer. It is therefore a target in the development of novel
anti-cancer therapies. The Angiogenesis Laboratory Amsterdam seeks to
unravel the fundamental processes and mechanisms
underlying angiogenesis and vascular development. The major aim is to use
new knowledge and technology for the development of new treatment modalities in the . |
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New issue of Angiogenesis |
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 Special issue on novel signaling pathways
in angiogenesis
Guest editors:
Roy Bicknell &
Judy R. van Beijnum
In memoriam dr.
Judah Folkman
Tribute paper
dr. Folkman by Domenico Ribatti |
Topics:
Slits and roundabouts in
cancer
Notch signaling in
endothelium
Netrins and UNC5 in
angiogenesis Neuropilin regulation of
angiogenesis
Sprouty
proteins as masterminds
TLR, RAGE and HMGB1
signaling
Wnt/frizzled signaling
Hedgehogs in development
NF-κB,
a new player in angiostasis
Endoglin in vascular diseases
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News item from the Angiogenesis Laboratory |
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'From
jellyfish to mouse to man; luminous mice aid cancer research' In:
Mare, weekly journal of the Leiden University.
Leiden University researchers have developed a nude
mouse with fluorescent blood vessels. This mouse is developed as a tool
for cancer research. Together with researchers from the Angiogenesis
Laboratory in Maastricht this mouse was described and shown to be useful
for the study of human cancer.
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 A
transgenic Tie2-GFP athymic mouse model; a tool for vascular biology in
xenograft tumors.
Hillen et al. Biochem Biophys Res Commun.
368:364-7,
2008.
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Recent research
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Other recent findings |
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 Isolation
of tumor endothelial cells
Van Beijnum et al. Nature
protocols, 2008
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Development of small-molecule topomimetics of
anginex.
Dings et al. J.Natl.Cancer Inst., 2006. |
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 The
galectin profile of the endothelium.
Thijssen et
al. Am. J. Pathol., 2008. |
Epigenetic regulation of
angiogenesis
Hellebrekers et
al. Cancer Res., 2007. |
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 Insight in the working mechanism of the in-house
developed angiogenesis inhibitor Anginex.
Thijssen et al. PNAS, 2006.
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 Interleukin-21,
a novel angiogenesis inhibitor.
Castermans et al. Blood,
2008
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Making tumors vulnerable to
the immune system by angiostasis.
Griffioen,
Cancer Immunol. Immunother., 2008. |
 A quantum dot-based probe for
molecular imaging of angiogenesis.
Mulder et
al. Nano Letters, 2006.
Imaging of angiogenesis
Mulder et
al. FASEB J., 2007 |
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NF-kappaB in angiogenesis inhibition
Tabruyn &
Griffioen, Cell Death Diff., 2007
No
lymph angiogenesis in primary breast carcinoma.
Van der Schaft et al. Cancer Lett., 2007.
Anginex-labeled liposomes for targeting of tumor endothelium
Brandwijk et al. Bioconj Chem., 2007
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Novel targets on tumor endothelial cells.
Van Beijnum et al.
Blood, 2006.
Anti-angiogenesis enhances
leukocyte infiltration in tumors.
Dirkx et al. FASEB J.,
2006.
A new entry in
angiostatic therapy
Griffioen, Blood, 2008. |
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NEWS & EVENTS
The Angiogenesis Laboratory
Amsterdam in
the news (articles only in Dutch)
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Tracer, April 2009
 Medische
Oncologie March, 2007
De Volkskrant, September 9th, 2006
More
news
You are visitor
 Last updated on
April 26th, 2009 |
Mare, Leids Universitair
weekblad, March, 2008
 C2W
Life Scieces, Chemisch Tijdschrift, March, 2007
 Summum,
December 20th, 2006 |
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